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University of Iowa Hospitals & Clinics

Iowa CIty, Iowa

Suncoast Skin Solutions

Tampa, Florida

University of Illinois Cancer Center

Chicago, Illinois

Eastern Virginia Medical School

Norfolk, Virginia

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Infusion Associates

Plymouth, Minnesota



University of Illinois Chicago College of Dentistry

Chicago, Illinois

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Fred Hutchinson Cancer Center

Seattle, Washington

Ann & Robert H. Lurie Children’s Hospital of Chicago

Chicago, Illinois

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Queen's Health System

Honolulu, Hawaii

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GI Alliance Research

Baton Rouge, Louisiana

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GI Alliance

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GI Alliance Research

Sun City, Arizona

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Daiichi Sankyo

Basking Ridge, New Jersey

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GI Alliance Research

Sun City, Arizona


Madison, Wisconsin

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Naples, Florida

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DescriptionThe research project is focused for "targeting Cdc42 to rejuvenate aged hematopoietic and intestinal stem cells". The objective is to demonstrate that CASIN and related small molecules targeting Cdc42 show selective activity toward Cdc42 in murine and human hematopoietic and intestinal stem/progenitor cells, can restore a youthful polarity and epigenetic clock, and improve engraftment potential.Cincinnati Children's Research and Training at a Glance: Among the top in NIH funding for pediatric research institutions Over 1.4 million square feet of research laboratory space 900+ scientists conducting basic, translational, and clinical research Over 2000 publications annually in top-tier journals

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