Senior Research Scientist, High Content Imaging Specialist - Gene Editing and Screening (GES) Core Facility, Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Location: New York, New York
Academic / Research
Internal Number: 66477
$80,000 - $95,000
Memorial Sloan Kettering Cancer Center (MSK) is one of the world's premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers.
The Gene Editing and Screening (GES) Core Facility (https://www.mskcc.org/research-advantage/core-facilities/rnai-core) is recruiting a senior level scientist to provide high content cell-based screening (HCS) and small molecule high throughput screening (HTS) for researchers at MSKCC and outside clients. Arrayed small molecule and siRNA libraries, along with pooled functional genomics CRISPR-Cas9 and shRNA libraries, are offered for such screens. Core services include: assay development, performing large screens, data analysis, hit calling, confirmation and validation of hits, statistical calculations, dose response curves, drug and radiation synergies, synthetic lethality, and signaling pathway associations.
Develop cell-based and non- cell-based assays for HCS and HTS screens
Perform arrayed RNAi, CRISPR, and small molecule screening experiments in a high-throughput screening format
Acquire large-scale image / screening data and perform statistical data analysis
Collect and enter data, assist in analyzing data, preparation of reports and manuscripts.
Maintain and develop protocols for laboratory automation including chemical inventory
Attend and participate in project meetings, assist in preparing and conducting experiments following established procedures or protocols, summarize results of experiments performed, and assist in interpreting the results of studies
Assist with maintaining, testing and/or implementation of robotics and automation
Interact with students / other laboratory members: assist with work as directed by the PI
Education and experience:
Ph.D. in cell or molecular biology or related field required
Extensive hands-on experience with large scale tissue culture
Minimum of 3-5 years experience in running microscopy-based studies
Experience in advanced image analysis (i.e. ImageJ, Zen Blue, Columbus)
Management of laboratory robotic equipment
Technical Knowledge and Competencies:
Experience with HCS and HTS assay development (biochemical/ cell-based) required
Capacity to handle multiple tasks and competing demands under tight timeframes
Ability to work under pressure, manage competing deadlines and priorities in a fast-paced research institute environment; respect project confidentiality
Ability to summarize detailed issues in a concise and structured manner
Ability to understand and carry out instructions; solve problems in complex situations
Ability to interact with all levels of staff in a professional manner
Must demonstrate excellent interpersonal and communication skills
Excellent verbal and written communication skills required
Capacity to exhibit adept multi-tasking and organizational skills required
Willingness to work independently and in a collaborative team environment
If you have any questions about this job opportunity, please contact:
Dr. Ralph Garippa
Please include a cover letter, brief statement of prior research experience and research interests, CV, and contact information for three references in your application submission.
Salary: $80,000 - $95,000
MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.
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At Memorial Sloan Kettering (MSK), we’re not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we’re driving excellence and improving outcomes. For the 28th year, MSK has been named a top hospital for cancer by U.S. News & World Report. We are proud to be on Becker’s Healthcare list as one of the 150 Great Places to Work in Healthcare in 2018, as well as one of Glassdoor’s Employees’ Choice Best Place to Work for 2018. We’re treating cancer, one patient at a time. Join us and make a difference every day.